Thermo Fisher Scientific FLT3 Polyclonal Antibody
FLT3 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 시료에 반응합니다. IHC(P) 및 ELISA에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS buffer에 0.1% sodium azide가 포함되어 있으며, 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 8 µg/mL
- Note: Heat-induced antigen retrieval in pH 6.0 citrate buffer recommended.
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from internal region of human FLT3 / CD135 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550231 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Rabbit (95%); Hamster (85%); Bovine, Dog, Panda, Horse (80%) - For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
- After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
FLT3 is a tyrosine protein kinase that belongs to the growth factor receptor tyrosine kinase family.
The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, inducing homodimer formation and autophosphorylation.
Activated FLT3 subsequently phosphorylates multiple cytoplasmic effector molecules involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow.
Mutations causing constitutive activation are associated with acute myeloid leukemia and acute lymphoblastic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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