Thermo Fisher Scientific PD-L1/PDCD1LG1/CD274/B7-H1 (Cancer Immunotherapy Target) Recombinant Rabbit Monoclonal Antibody (PDL1, 4280R)
PD-L1 단백질을 표적하는 Thermo Fisher의 재조합 토끼 단클론 항체로, 암 면역치료 연구에 최적화됨. IHC(P)에서 1–2 µg/mL 농도로 사용 가능. HEK293 발현 시스템 기반, Protein A/G 정제, 4°C 보관. 인간 PD-L1(aa 200–290)에 특이적.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PDL1, 4280R |
| Immunogen | KLH-conjugated linear peptide corresponding to human PD-L1 (amino acids 200–290) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a member of the B7 family. It binds to the programmed death receptor 1 (PD-1), which negatively regulates T-cell receptor (TCR) signaling. PD-L1 ligation decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be upregulated upon IFN-γ stimulation, suggesting its role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 29126-RBM10-P1_PDL1_CD274_Q9NZQ7-1_Rabbit.svg, 29126-RBM10-P1_PDL1_CD274_Q9NZQ7-1_Rabbit_PDP.jpeg)
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