Thermo Fisher Scientific Human ZBTB4 Synthetic Peptide
인간 ZBTB4 단백질의 C-말단 부근 18개 아미노산 서열을 기반으로 한 합성 펩타이드. 항체 PA5-21084의 블로킹 펩타이드로 사용 가능. 메틸화 DNA 결합 및 전사 억제 연구에 적합. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Human ZBTB4 Synthetic Peptide
Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to an 18 amino acid sequence near the carboxy terminus of human ZBTB4.
PEP-1198 can be used as a blocking peptide with polyclonal antibody PA5-21084.
Target Information
The ZBTB family of proteins consists of diverse zinc finger proteins containing a BTB (BR-C, ttk, and bab) domain. Similar to Kaiso, a zinc-finger protein that binds methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription.
ZBTB4 associates with the Sin3/histone deacetylase co-repressor complex and represses expression of P21CIP1 as part of a heterodimeric complex with Miz1.
In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, indicating that ZBTB4 is a critical determinant of the cellular response to p53 activation.
HIPK2, a kinase involved in proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal conditions; this degradation increases with DNA damage.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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