Thermo Fisher Scientific Integrin beta 7 Polyclonal Antibody
Human 반응성을 가진 sheep 유래 polyclonal Integrin beta 7 항체로, Western blot 및 Flow cytometry에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 염결합 및 면역세포 이동 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 0.25 µg per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CHO-derived recombinant human Integrin beta 7 long isoform Glu20–His723 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609116 |
Product Specific Information
In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse Integrin beta 7 is observed and less than 1% cross-reactivity with recombinant human Integrin beta 2, beta 5, and beta 6 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin (LPAM-1), expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin (HML-1), expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes.
Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1, and fibronectin, while the ligand for HML-1 is E-cadherin (CD324).
Integrin beta 7 plays an important role in leukocyte adhesion to endothelial cells, promoting transmigration of leukocytes to extravascular spaces during the inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-47649_Integrin_beta_7_P26010-1_Sheep.svg, PA5-47649_Integrin_beta_7_P26010-1_Sheep_PDP.jpeg)
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