Thermo Fisher Scientific Phospho-ROS1 (Tyr2274) Polyclonal Antibody
ROS1 단백질의 Tyr2274 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin)에서 검증됨. Human, Mouse, Rat 반응성. 고순도 정제 및 안정적 PBS/glycerol 저장용액 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5105915
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-ROS1 (Tyr2274) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ROS1 (Accession P08922), corresponding to amino acid residues around phosphorylated Tyr2274. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817314 |
Product Specific Information
Antibody detects endogenous levels of ROS1 only when phosphorylated at Tyr2274.
Target Information
ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor.
Protein kinases transfer a phosphate group from ATP to substrate proteins, mediating signal transduction in eukaryotic cells.
They regulate cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
The protein kinase family includes over 500 gene products, classified into 8 major groups based on catalytic domain sequences:
- Tyrosine kinases (TK)
- Serine/threonine kinases (STK)
The TK group mainly regulates cell-cell interactions such as differentiation, adhesion, motility, and death.
Approximately 90 TK genes have been sequenced, including:
- 58 receptor TKs (EGFR, EPH, FGFR, PDGFR, TRK, VEGFR families)
- 32 cytosolic TKs (ABL, FAK, JAK, SRC families)
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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