Thermo Fisher Scientific TRAIL Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human TNFSF10/TRAIL/APO-2L.

Target Information

TRAIL is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells despite being expressed at significant levels in most normal tissues.
TRAIL binds to several members of the TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly TNFRSF11B/OPG.
Its activity may be modulated by binding to decoy receptors (TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, TNFRSF11B/OPG) that cannot induce apoptosis.
Binding of TRAIL protein to its receptors triggers activation of MAPK8/JNK, caspase 8, and caspase 3.
Receptors for TRAIL include two death domain-containing receptors (DR4, DR5) and two decoy receptors (DcR1, DcR2) lacking the intracellular signaling death domain.
TRAIL is a type II membrane protein expressed in various human tissues and induces apoptosis and NF-κB activation similar to TNF and Fas ligand.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.