Thermo Fisher Scientific ZO-2 Polyclonal Antibody
ZO-2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 실험에 적합하며, 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, 안정화제가 포함된 PBS에 보관.
- 카탈로그번호
- 630-020
- 판매단위
- pk
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Thermo Fisher Scientific ZO-2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of AH SKR GYY SQP SRY RDT EL (human ZO-2 protein, amino acids 19–1167) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: A431, HEK293
- Cellular location: Membrane, Cellular junction
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. It is absent in non-hematopoietic cell lines and tissues.
CD45 plays a crucial role in lymphocyte development and antigen signaling, regulating Src-family kinases and JAK kinases. It exists as multiple isoforms due to alternative splicing, differing in extracellular domains but sharing transmembrane and cytoplasmic domains.
CD45RA is an isoform with restricted expression among lymphoid cell subtypes. CD45 regulates T- and B-cell receptor signaling, cytokine signaling, and cell survival pathways, including integrin-mediated signal transduction and apoptosis regulation.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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