Thermo Fisher Scientific HTR2A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total 5HT2A Receptor.

Target Information

In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively.
Serotonin mediates its effects through several G protein-coupled receptors, designated 5-HT receptors or alternatively SR receptors.
The SR-2 receptors consist of three subtypes: SR-2A, SR-2B, and SR-2C, which activate phospholipase C and release intracellular calcium stores in response to serotonin.

• SR-2A: Involved in tracheal smooth muscle contraction, bronchoconstriction, and aldosterone production. Thought to play a role in psychiatric disorders such as depression and schizophrenia.
• SR-2B: Expressed in embryonic and adult cardiovascular tissues, gut, and brain; important in cardiac pathology.
• SR-2C: Mediates effects of atypical antipsychotic drugs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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