Thermo Fisher Scientific Podoplanin Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

• Synthetic peptide sequence: 227–238aa, VVMRKMSGRYSP
• Add 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin-type 1 glycoprotein with a molecular weight of 40–43 kDa.
It is expressed in various tumors and normal cells, notably lymphatic epithelial and follicular dendritic cells.
Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells.
As a regulator of lymphatic endothelium, it likely contributes to podocyte morphology maintenance.
Podoplanin serves as a ligand for CLEC-2, with expression linked to increased tumor invasiveness and metastasis.
It participates in cell migration, metastasis formation, and tumor invasion.
Expression can be induced via Src activation of Cas, and recent studies suggest presence on Th17 cells.
Initial studies indicate expression in a small population of CD4+ cells from human PBMC.
Dysfunction of podoplanin has been associated with lymphangioma and subglottis neoplasm.
It is also proposed as a marker for lung injury due to its physiological role.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.