Thermo Fisher Scientific UBASH3A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• This antibody is expected to recognize both reported isoforms (NP_061834.1; NP_001001895.1).
• Tested in Peptide ELISA: antibody detection limit dilution 1:8,000.

Target Information

TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), also known as STS-2 or CLIP4, is a 661 amino acid protein that localizes to both the nucleus and cytoplasm and contains one SH3 domain and one UBA domain. It is highly expressed in thymus, bone marrow, spleen, and peripheral blood leukocytes. TULA functions as a homodimer or homo-oligomer that interferes with receptor-type tyrosine kinase degradation and promotes accumulation of activated receptors on the cell surface. It is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA, located on human chromosome 21, may be involved in the pathogenesis of type I diabetes. Multiple isoforms are produced due to alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.