Thermo Fisher Scientific TGFB1 Monoclonal Antibody (OTI3B6), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of αV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-β binding proteins.

Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor (TGF-LAP; TGF-latency associated peptide), and a specific binding protein known as LTBP. TGF beta-1 regulates proliferation, differentiation, adhesion, and migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates other growth factors.

TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, found in either a latent form (TGFB1 homodimer + LAP homodimer + latent TGFB1-binding protein) or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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