Thermo Fisher Scientific DAP3 Monoclonal Antibody (OTI2D4), TrueMAB

Thermo Fisher Scientific DAP3 Monoclonal Antibody (OTI2D4), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution

• 1:2,000

Product Specifications

Target Information

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence and biochemical properties, preventing easy recognition by sequence homology.
This gene encodes a 28S subunit protein that also participates in apoptotic pathways initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. The protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Splice variants differing in the 5′ UTR have been found for this gene; both variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.