Thermo Fisher Scientific FBXW7 Monoclonal Antibody (OTI6H1), TrueMAB
FBXW7 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot에 적합. 인간 시료에 반응하며, 고순도 친화 크로마토그래피 정제. PBS/BSA/glycerol buffer에 보관, 연구용으로만 사용.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6H1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–354 of human FBXW7 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family characterized by a ~40 amino acid F-box motif. These proteins form part of the SCF (SKP1–Cullin–F-box) ubiquitin ligase complex involved in phosphorylation-dependent ubiquitination.
FBXW7 belongs to the Fbws class, containing WD-40 domains and seven tandem WD40 repeats. It binds directly to cyclin E and likely mediates its ubiquitin-dependent degradation.
Mutations in FBXW7 have been found in ovarian and breast cancer cell lines, suggesting a role in tumorigenesis. Multiple transcript variants encoding different isoforms exist for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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