Thermo Fisher Scientific PTGS2 Monoclonal Antibody (OTI5F12), TrueMAB
PTGS2(COX2) 단백질을 인식하는 Mouse monoclonal antibody. Western blot과 IHC(P)에서 검증됨. Human 시료에 반응하며, 1 mg/mL 농도의 액상 형태로 제공. Affinity chromatography로 정제되어 안정적인 신호 검출 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 18–260 of human PTGS2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins.
The conversion involves two steps:
- Cyclooxygenase (COX) reaction converting arachidonate to prostaglandin G2 (PGG2)
- Peroxidase reaction reducing PGG2 to prostaglandin H2 (PGH2)
COX2 is constitutively expressed in some tissues (endothelium, kidney, brain) and up-regulated under pathological conditions such as cancer and inflammation.
Up-regulation is associated with increased cell adhesion, phenotypic changes, apoptosis resistance, and tumor angiogenesis.
In cancer cells, COX2 is key in producing prostaglandin E2 (PGE2), which modulates motility, proliferation, and apoptosis resistance.
COX2 is naturally inhibited by calcitriol (active Vitamin D) and transcriptionally repressed by glucocorticoids.
It is a target of NSAIDs such as aspirin, which reduce inflammation-driven pain and swelling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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