Thermo Fisher Scientific NPHS2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Centrifuge briefly prior to opening.

Target Information

The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs.
Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria.
The human NPHS2 gene maps to chromosome 1q25–q31 and encodes a 383 amino acid protein.
Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini.
Transmembrane and cytoplasmic portions of Podocin share homology with the corresponding regions of the stomatin family proteins.
Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.