Thermo Fisher Scientific MKL2 Monoclonal Antibody (CL1546)
Human MKL2 단백질을 인식하는 mouse monoclonal antibody(CL1546)로 Western blot 및 Immunocytochemistry에 적합. Recombinant human MKL2를 immunogen으로 사용하며 Protein A로 정제. 1 mg/mL 농도의 액상형, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL1546 |
| Immunogen | Recombinant protein corresponding to Human MKL2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637243 |
Product Specific Information
Immunogen sequence:
QRPGPMELVE KNILPVDSSV KEAIIGVGKE DYPHTQGDFS FDEDSSDALS PDQPASQESQ GSAASPSEPK VSESPSPVTT NTPAQFASVS PTVPEFLKTP PTADQPPPRP AAPVLPTNTV SSAKPGPALV KQSHPKNPHighest antigen sequence identity to orthologs:
- Mouse: 89%
- Rat: 54%
Binds to an epitope located within the peptide sequence FASVSPTVPEFLKTP as determined by overlapping synthetic peptides.
Target Information
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), mediating transient responses of cellular genes to growth stimulation. SRF regulates muscle gene expression by recruiting myogenic factors and is essential for vertebrate mesoderm formation and cardiovascular system development.
Myocardin, together with SRF, activates cardiac muscle promoters. Myocardin-related transcription factors A (MRTF-A) and B (MRTF-B) interact with SRF to stimulate transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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