Thermo Fisher Scientific TJP1/ZO-1 Recombinant Rabbit Monoclonal Antibody (BLR092G)
TJP1/ZO-1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합합니다. 인간 및 생쥐 시료에 반응하며, 고순도 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR092G |
| Immunogen | Peptide representing a region between residue 650 and 700 of Human tight junction protein ZO-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ZO-1 forms complexes with either ZO-2 or ZO-3. These proteins can also associate with claudin, occludin, and F-actin at tight junction strands, providing a linkage between the actin cytoskeleton and the tight junction.
ZO-1 expression is significantly reduced in many breast cancer lines.
ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions. Unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.
ZO-1 is a cytoplasmic membrane-associated protein located at intercellular tight junctions and may be involved in signal transduction at cell-cell junctions.
Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene.
Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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