Thermo Fisher Scientific MCM7 Recombinant Rabbit Monoclonal Antibody (MCM7, 2756R)
인간 MCM7 단백질을 인식하는 재조합 토끼 단일클론 항체. Western blot 및 IHC(Paraffin) 적용 가능. HEK293 세포 발현, Protein A/G 정제, 무보존액 PBS 용액 형태. -20°C 또는 -80°C 보관. 연구용 전용.
- 카탈로그번호
- 4176-RBM6-P1ABX
- 판매단위
- pk
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Thermo Fisher Scientific MCM7 Recombinant Rabbit Monoclonal Antibody (MCM7, 2756R)
Applications and Tested Dilution
- Western Blot (WB): 1–2 µg/mL
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MCM7, 2756R |
| Immunogen | Recombinant fragment of human MCM7 (aa195–319) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) essential for the initiation of eukaryotic genome replication. The hexameric MCM complex is a key component of the pre-replication complex (pre_RC), involved in replication fork formation and recruitment of DNA replication proteins.
The complex (including MCM2, 4, 6, and 7) possesses DNA helicase activity and functions as a DNA unwinding enzyme. Cyclin D1-dependent kinase CDK4 associates with MCM7 and may regulate its interaction with tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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