Thermo Fisher Scientific CD33 Monoclonal Antibody (CD33-4D3)
CD33 단백질을 표적하는 Mouse IgG2b 단일클론 항체로, 인간 시료에 반응합니다. IHC(P) 및 유세포분석에 적합하며, 단백질 A로 정제된 액상 형태입니다. 단기 4°C, 장기 -20°C 보관이 권장되며, AML 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Flow Cytometry (Flow) | 0.5–5 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD33-4D3 |
| Immunogen | Recombinant protein of CD33 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C (short term); -20°C (long term), avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human liver
- Cellular location: Membrane
Target Information
CD33 is a transmembrane protein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatases SHP-1 and SHP-2, mediating inhibitory signaling and receptor internalization via ubiquitin pathways.
CD33 is expressed on cells of the myelomonocytic lineage, including granulocyte and macrophage precursors in the bone marrow, but not on pluripotent stem cells. It binds sialic acid residues on N- and O-glycans and is a key therapeutic and diagnostic target in acute myeloid leukemia (AML).
Additionally, CD33 serves as a useful marker for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Dysregulation of CD33 is associated with diseases such as gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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