Thermo Fisher Scientific CD33 Monoclonal Antibody (WM53)
인간 CD33 단백질을 인식하는 Mouse IgG2b 단클론 항체로, IHC(P) 및 Flow Cytometry에 적합합니다. 단백질 A로 정제된 액상 형태이며, 0.5 mg/mL 농도로 제공됩니다. CD33 표지 세포 연구 및 급성 골수성 백혈병 관련 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Flow Cytometry (Flow) | 0.5–5 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | WM53 |
| Immunogen | Recombinant CD33 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human liver
- Cellular location: Membrane
Target Information
CD33 is a transmembrane protein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatases SHP-1 and SHP-2, and are involved in ubiquitin-mediated receptor removal from the cell surface.
CD33 is expressed on cells of the myelomonocytic lineage, binding sialic acid residues in N- and O-glycans on cell surfaces. It serves as a therapeutic target for acute myeloid leukemia (AML).
Additionally, CD33 is present on granulocyte and macrophage precursors in bone marrow, but not on pluripotent stem cells, and is expressed on peripheral monocytes. It is a useful marker to distinguish myelogenous leukemia cells from lymphoid or erythroid leukemias.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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