Thermo Fisher Scientific PGR Monoclonal Antibody (OTI15C1), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors mediating the physiological effects of progesterone, crucial for reproductive processes such as pregnancy establishment and maintenance.
PR exists in two forms:

• PR-A (94 kDa): Contains a 165 amino acid deletion, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
• PR-B (120 kDa): Transcriptionally active form, responsible for gene activation related to endometrium maintenance and ovulation inhibition.

In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes conformational change, enabling dimerization and DNA binding to progesterone response elements (PRE), leading to activated transcription.
A null mutation in the PGR gene can cause pleiotropic reproductive abnormalities.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.

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