Thermo Fisher Scientific PGR Monoclonal Antibody (OTI5E8), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7 K MWCO, 0.5 mL, Product #89882).

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events such as pregnancy establishment and maintenance.
PR exists as two forms: Form A (94 kDa) and Form B (120 kDa), generated by alternative translation initiation sites.

• PR-B: Transcriptionally active form responsible for maintaining endometrium and pregnancy.
• PR-A: Lacks 165 amino acids at the N-terminus, exposing a 140 amino acid inhibitory domain (ID) that represses steroid hormone transcriptional activity.

In its inactive state, PgR forms a multiprotein complex including heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes conformational change, dimerizes, and binds to progesterone response elements (PREs), activating transcription.
A null mutation in the PGR gene leads to pleiotropic reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.

제품 이미지

(이미지 없음)