Thermo Fisher Scientific RGL1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

This antibody detects endogenous protein at a molecular weight of approximately 87 kDa.
Purity is greater than 95% by SDS-PAGE.

Target Information

Ral GDS (Ral guanine nucleotide dissociation stimulator) is a guanine nucleotide exchange factor (GEF) that activates Ral and is implicated in oncogenic Ras-induced cell transformation.
RGL1 (Ral guanine nucleotide dissociation stimulator-like 1), also known as RGL or RalGDS-like 1, is a 768 amino acid protein that functions as a putative GEF.
It is strongly expressed in brain, heart, spleen, kidney, and testis, and acts as a downstream effector in Ras and Ral signaling pathways.
RGL1 contains an N-terminal Ras-GEF domain and a C-terminal Ras-interacting domain that interacts with the GTP-bound form of Ras through its effector loop.
Due to its similarity to Ral GDS, RGL1 may be implicated in carcinogenesis. Two isoforms exist due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.