Thermo Fisher Scientific Mcl-1 Polyclonal Antibody
Thermo Fisher Scientific의 Mcl-1 폴리클로날 항체로, Mouse Mcl-1 단백질을 검출하기 위한 연구용 항체입니다. Western blot과 ELISA에 적합하며, 고순도 친화성 정제 제품입니다. -20°C 보관으로 안정성이 우수합니다.
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- 600-401-394x (2개 옵션)
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Mcl-1 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:10,000
ELISA
- Tested Dilution: 1:10,000–1:50,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to an internal region of mouse Mcl-1 conjugated to Keyhole Limpet Hemocyanin (KLH) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum.
Target Information
MCL1 (Myeloid cell leukemia-1) belongs to the Bcl-2 family and is involved in cell viability regulation, differentiation, and apoptosis control. Isoform 1 inhibits apoptosis, while isoform 2 promotes it.
MCL1 expression increases in response to DNA-damaging agents such as ionizing radiation, UV, and alkylating drugs. It is associated with mitochondrial localization and complements bcl-2 expression during myeloid cell differentiation.
MCL1 interacts with pro-apoptotic Bcl-2 family members (Bim, Bak) to inhibit apoptosis. It is essential for embryogenesis and lymphocyte development and exists as two isoforms: MCL1L (anti-apoptotic) and MCL1S (pro-apoptotic).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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