Thermo Fisher Scientific SCNN1D Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7
• Predicted reactivity: Chimpanzee (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal.
Of the type II receptors, SNX6 interacts strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII.
Of the type I receptors, SNX6 interacts only with inactivated TbetaRI.
SNXs 1–4 also interact with the transforming growth factor-beta receptor family, showing different receptor preferences.
Strong heteromeric interactions are also seen among SNX1, -2, -4, and -6, suggesting formation of oligomeric complexes in vivo.
These findings provide evidence for the association of the SNX family with receptor serine-threonine kinases.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.