Thermo Fisher Scientific PCNA Monoclonal Antibody (OTI6B6), TrueMAB

Thermo Fisher Scientific PCNA Monoclonal Antibody (OTI6B6), TrueMAB

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

PCNA (polymerase delta auxiliary protein) is essential for DNA replication and repair, including excision and mismatch repair pathways.
It interacts with CDK inhibitor p21, endonucleases Fen1 and XPG, and DNA methyltransferase (MCMT).
PCNA serves as a marker for proliferating cells and is useful for assessing tumor proliferation status.
Located in the nucleus, PCNA acts as a cofactor for DNA polymerase delta, forming a homotrimer that enhances leading strand synthesis.
Upon DNA damage, PCNA is ubiquitinated and participates in RAD6-dependent DNA repair.
Two transcript variants encoding the same protein are known, and pseudogenes are present on chromosome 4 and the X chromosome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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