Thermo Fisher Scientific NOXA Polyclonal Antibody
Rabbit polyclonal antibody recognizing human NOXA protein for apoptosis research. Suitable for WB and IHC applications. Unconjugated liquid form with reliable specificity. Ideal for studies on p53-mediated apoptotic pathways.
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Thermo Fisher Scientific NOXA Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (IHC) | 1:20–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NOXA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856735 |
Product Specific Information
Immunogen sequence:
QEIWRQTELP AETSESDIQT LLLRNLTASK TCMRGLLQKS FLRRCTFHQF E
Target Information
Apoptosis is related to many diseases and developmental processes. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA.
A new p53 target gene, Noxa, encodes a protein belonging to the BH3-only proapoptotic subfamily. Noxa and PUMA are transcriptional targets of p53 and BH3-only proteins.
X-ray irradiation increases p53-dependent Noxa mRNA and protein levels. When ectopically expressed, Noxa interacts with anti-apoptotic Bcl-2 family members, activating caspase-9.
Like PUMA, Noxa localizes to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may act as direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa are associated with impaired tumor development.
Additional Information
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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