Thermo Fisher Scientific RUNX1T1 Monoclonal Antibody (OTI1H1), TrueMAB
Human RUNX1T1 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 고순도 친화 크로마토그래피 정제, 무보존제 PBS 버퍼, 동결건조 형태로 제공됩니다. 연구용으로 AML 관련 RUNX1T1 분석에 활용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H1 |
| Immunogen | Full-length human recombinant RUNX1T1 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia (AML), particularly the M2 subtype, the t(8;21)(q22;q22) translocation is a common abnormality, producing a chimeric gene combining the RUNX1 and RUNX1T1 regions. The resulting protein associates with the nuclear corepressor/histone deacetylase complex, inhibiting hematopoietic differentiation. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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