Thermo Fisher Scientific PR3 Monoclonal Antibody (PR3G-2)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50

-

Immunohistochemistry (Frozen) (IHC (F))

1:50

-

Flow Cytometry (Flow)

1:50

-

ELISA (ELISA)

1:50

-

Functional Assay (Functional)

1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

PR3G-2

Immunogen

Crude alpha granule extract. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PR3,uniProtId:P24158-1,ncbiNodeId:9606,antigenRange:1-256,antigenLength:256,antigenImageFileName:MA1-40218_PR3_P24158-1_House_mouse.svg,antigenImageFileNamePDP:MA1-40218_PR3_P24158-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

View additional formats

• FITC
• Request custom conjugation

Form

Liquid

Concentration

0.1 mg/mL

Purification

Protein G

Storage buffer

PBS with 0.1% BSA

Contains

no preservative

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2268921

Product Specific Information

MA1-40218 detects Proteinase 3 from human samples.

MA1-40218 has been successfully used in ELISA, flow cytometry, immunohistochemistry (frozen), and Western blot applications.

The MA1-40218 immunogen is human PR3.

Endotoxin <24 EU/mg.

Target Information

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.