Thermo Fisher Scientific ZNF638/NP220 Polyclonal Antibody
ZNF638/NP220 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합. 인간 ZNF638(1928–1978) 영역을 면역원으로 사용. 액상 형태, 4°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1928 and 1978 of Human zinc finger protein 638 (Nuclear protein 220) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass transcriptional activation or repression.
NP220 (Nuclear protein 220), also designated Zinc finger protein 638 (ZNF638), is a 1978 amino acid protein containing one matrin-type zinc finger and two RRM (RNA recognition motif) domains, suggesting a role in transcriptional regulation.
NP220 binds to double-stranded DNA fragments by recognizing clusters of cytidines and interacts with FHL-2. It is thought to be phosphorylated by ATM or ATR upon DNA damage.
NP220 exists as five isoforms due to alternative splicing; isoform five is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL) cases, including mycosis fungoides and Sezary syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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