Thermo Fisher Scientific ALK Monoclonal Antibody (OTI10D7), TrueMAB
인간 ALK 단백질을 표적으로 하는 Mouse IgG2b 단클론 항체로, Western Blot 및 Luminex 분석에 적합합니다. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 뇌 발달 및 종양 관련 ALK 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Luminex (LUM)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10D7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a crucial role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with several tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often generate fusion genes such as NPM-ALK, which have oncogenic properties.
ALK is a receptor tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
Its expression and function are critical in specific neurons of the nervous system.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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