
Thermo Fisher Scientific ECP Polyclonal Antibody
Thermo Fisher Scientific의 ECP Polyclonal Antibody는 인간 ECP(RNASE3)를 인식하는 토끼 유래 IgG 항체입니다. IHC, ICC/IF, ELISA 등 다양한 분석에 사용 가능하며, 단백질 A 정제 및 고순도 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ECP, amino acids 45–160 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ECP (eosinophil cationic protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein belonging to the pancreatic ribonuclease family.
ECP localizes to the granule matrix of eosinophils and plays a role in immune response. It acts as a cytotoxin, neurotoxin, and helminthotoxin secreted by activated human eosinophils, exhibiting anti-parasitic, antibacterial, and ribonucleolytic activities.
High levels of ECP are associated with eosinophilic inflammation, active asthma, and allergic diseases. It is also linked to the neurotoxic Gordon phenomenon characterized by ataxia, muscular rigidity, paralysis, and tremor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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