Thermo Fisher Scientific MPP5 Monoclonal Antibody (OTI2D3), TrueMAB
MPP5 단백질을 타겟으로 한 Mouse monoclonal antibody. Western blot과 Flow cytometry에 적합하며, Human, Dog, Rat 시료에 반응. 동결건조 형태로 제공되며, PBS buffer에 trehalose 포함. 세포 극성 유지 및 신경 발생 관련 연구에 유용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D3 |
| Immunogen | Full length human recombinant protein of human MPP5 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
MPP5 (Membrane Protein, Palmitoylated 5) plays a critical role in neurogenesis and hematopoiesis. It is essential for establishing and maintaining cell polarity in epithelial cells and neurons, functioning within the Par-3 complex to maintain tight junctions.
Mutations in MPP5 are linked to severe neurological impairments such as global developmental delay (GDD) and behavioral changes. In animal models, MPP5 is involved in the early differentiation of multipotent progenitors and supports long-term lineage-specific development in myeloid and lymphoid cells. Disruption of MPP5 function leads to significant developmental and cellular abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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