Thermo Fisher Scientific MPP5 Monoclonal Antibody (OTI2D3), TrueMAB

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Flow Cytometry (Flow)

1:100

-

Product Specifications

Species Reactivity

Dog, Human, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI2D3

Immunogen

Full length human recombinant protein of human MPP5 produced in HEK293T cell. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MPP5,uniProtId:Q8N3R9-1,ncbiNodeId:9606,antigenRange:1-675,antigenLength:675,antigenImageFileName:CF504451_MPP5_Q8N3R9-1_House_mouse.svg,antigenImageFileNamePDP:CF504451_MPP5_Q8N3R9-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

MPP5 (Membrane Protein, Palmitoylated 5) plays a critical role in neurogenesis and hematopoiesis. This protein is crucial for establishing and maintaining cell polarity in epithelial cells and neurons. It is involved in the Par-3 complex, which contributes to maintaining tight junctions in epithelial cells. Mutations in MPP5 have been associated with severe neurologic impairments, including global developmental delay (GDD) and behavioral changes. In animal models, MPP5 is highly involved in the early differentiation of multipotent progenitors and supports long-term lineage-specific contributions, primarily in myeloid and lymphoid cells. MPP5 variants disrupt normal cellular function, leading to profound developmental and functional abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.