Thermo Fisher Scientific PNPase Recombinant Rabbit Monoclonal Antibody (24H24L10)

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100 – 1:500

Product Specifications

Product Specific Information

This antibody is predicted to react with Mouse, Rat, and Bovine.

Target Information

PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondrial) is an RNA-binding protein implicated in numerous RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3′-to-5′ direction. PNPT1 is a component of the mitochondrial degradosome (mtEXO) complex that degrades 3′ overhang double-stranded RNA in an ATP-dependent manner. It is required for correct processing and polyadenylation of mitochondrial mRNAs. Additionally, it plays roles in cytoplasmic RNA import, mitochondrial morphogenesis, respiration, electron transport chain expression regulation, miRNA stability, and RNA surveillance. Mutations can lead to combined oxidative phosphorylation deficiency 13 (COXPD13) and autosomal recessive deafness 70 (DFNB70).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.