Thermo Fisher Scientific DLC1 Polyclonal Antibody
Thermo Fisher Scientific의 DLC1 폴리클로날 항체는 Mouse와 Rat에서 반응하며, Western blot 및 ELISA에 적합합니다. 인간 DLC1 단백질(aa 204-463) 기반 면역원으로 제작되었으며, 액상 형태로 제공됩니다. 암 억제 관련 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 204–463 of human DLC1 (NP_079043.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.58 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914240 |
Product Specific Information
- Positive test controls: Mouse lung
- Subcellular localization: Cell junction, Cytoplasm, Membrane, Peripheral membrane protein, Focal adhesion
Immunogen sequence:
DAPKVNAVDT LNVKDIAPEK QLLNSAVIAQ QRRKPDPPKD ENERSTCNVV QNEFLDTPCT NRGLPLLKTD FGSCLLQPPS CPNGMSAENG LEKSGFSQHQ NKSPPKVKAE DGMQCLQLKE TLATQEPTDN QVRLRKRKEI REDRDRARLD SMVLLIMKLD QLDQDIENAL STSSSPSGTP TNLRRHVPDL ESGSESGADT ISVNQTRVNL SSDTESTDLP SSTPVANSGT KPKTTAIQGI SEKEKAGKLT FWFCFLANLF
Target Information
This gene encodes a GTPase-activating protein that belongs to the rhoGAP family, which regulates small GTP-binding proteins. GAP family proteins are involved in signaling pathways controlling cytoskeletal organization.
DLC1 functions as a tumor suppressor gene in several cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants exist due to alternative promoters and splicing.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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