Thermo Fisher Scientific Presenilin Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 2–10 µg/mL

Product Specifications

Product Specific Information

• Positive control: Alzheimer’s disease brain
• Cellular location: Endoplasmic reticulum membrane

Target Information

Presenilin1 was initially identified as a marker of susceptibility to early-onset Alzheimer’s disease. Together with PEN2, nicastrin, and APH-1, Presenilin1 forms the γ-secretase protein complex, a membrane-bound aspartyl protease that cleaves certain proteins within the hydrophobic environment of the lipid bilayer. This cleavage plays a key role in signaling from several cell-surface receptors and is required for generating neurotoxic amyloid peptides central to Alzheimer’s disease pathogenesis. Like TACE and BACE protease families, γ-secretase cleaves amyloid precursor protein (APP) within its intramembrane region, producing either non-toxic p3 or toxic Aβ amyloid peptides. Accumulation of Aβ peptide is thought to precede Alzheimer’s disease. Multiple isoforms of Presenilin1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.