Thermo Fisher Scientific Presenilin Polyclonal Antibody
인간 Presenilin 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 2–10 µg/mL 농도로 사용 가능. Alzheimer’s disease 연구용으로 적합하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며 4°C 보관 권장.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the internal segment of human Presenilin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Alzheimer’s disease brain
- Cellular location: Endoplasmic reticulum membrane
Target Information
Presenilin1 was initially identified as a marker of susceptibility to early-onset Alzheimer’s disease. Together with PEN2, nicastrin, and APH-1, Presenilin1 forms the γ-secretase protein complex, a membrane-bound aspartyl protease that cleaves certain proteins within the hydrophobic environment of the lipid bilayer. This cleavage plays a key role in signaling from several cell-surface receptors and is required for generating neurotoxic amyloid peptides central to Alzheimer’s disease pathogenesis. Like TACE and BACE protease families, γ-secretase cleaves amyloid precursor protein (APP) within its intramembrane region, producing either non-toxic p3 or toxic Aβ amyloid peptides. Accumulation of Aβ peptide is thought to precede Alzheimer’s disease. Multiple isoforms of Presenilin1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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