Thermo Fisher Scientific CD204 Monoclonal Antibody (2F8), PE

Applications

• Flow Cytometry (Flow)
  Tested Dilution: Neat

Product Specifications

Additional Formats

• Unconjugated (MA5-16492)
• Biotin (MA5-16493)
• FITC (MA1-81060)
• Custom conjugation available

Product Specific Information

• Reconstitute with 1 mL of distilled water.
• After reconstitution, store undiluted at 4°C in the dark.
• For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
• Rat anti-Mouse CD204 antibody, clone 2F8, recognizes murine scavenger receptor class A (SRA) type I and II (CD204).

Target Information

CD204 encodes class A macrophage scavenger receptors, including three isoforms (1, 2, 3) generated by alternative splicing. These macrophage-specific trimeric membrane glycoproteins are involved in physiological and pathological processes such as atherosclerosis, Alzheimer’s disease, and host defense.

• Isoforms 1 and 2: functional receptors mediating endocytosis of modified LDLs.
• Isoform 3: non-functional in LDL uptake due to altered intracellular processing, retained in the endoplasmic reticulum, and exerts a dominant negative effect on other isoforms.
• Associated diseases: Barrett Esophagus, Prostate Cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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