Thermo Fisher Scientific ASK1 Polyclonal Antibody
ASK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, 고순도(>95%)로 정제됨. Human 및 Rat 반응성. 장기 보관 시 -20°C에서 안정적.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 43–90 of Human ASK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2802907 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated by various extracellular stimuli such as cytokines, growth factors, and environmental stresses. ASK1 activates MKK4 and MKK6, which in turn activate JNK and p38 MAP kinases. ASK1/MAPKKK5 is activated by TNFR and Fas through interaction with TRAF family members and Daxx. Overexpression induces apoptosis, while inactive ASK1 inhibits TNF-α-induced apoptosis. ASK1 is expressed in various human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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