Thermo Fisher Scientific IL17C Polyclonal Antibody
IL17C 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간 및 마우스 시료에 반응합니다. Western blot과 IHC(P) 적용 가능하며, 친화 크로마토그래피로 정제된 액상 항체입니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PA5103436
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL17C (Accession Q9P0M4), corresponding to amino acid residues R141–C191 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852777 |
Product Specific Information
Antibody detects endogenous levels of total IL17C.
Target Information
Cytokine that plays a crucial role in innate immunity of the epithelium, including response to intestinal bacterial pathogens, in an autocrine manner. Stimulates production of antibacterial peptides and proinflammatory molecules for host defense via NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing expression of antibacterial peptides (S100A8, S100A9, REG3A, REG3G). Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties by maintaining epithelial homeostasis or promoting inflammation. Enhanced IL17C/IL17RE signaling may lead to greater susceptibility to autoimmune diseases.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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