Thermo Fisher Scientific PD-L1 (CD274) Monoclonal Antibody (ZY349)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2–10 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: 0.5–5 µg/10^6 cells

Product Specifications

Product Specific Information

• Positive control: Human breast carcinoma
• Cellular location: Membrane

Target Information

Programmed death receptor ligand 1 (PD-L1, also known as B7-H1) is a member of the B7 family. PD-L1 binds to its receptor PD-1, which negatively regulates T-cell receptor (TCR) signaling. This interaction decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be upregulated upon IFN-γ stimulation, suggesting its role in tumor immune evasion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.