Thermo Fisher Scientific CYP51A1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: THP-1
• Predicted reactivity: Xenopus laevis (84%), Chicken (87%), Chimpanzee (98%), Bovine (94%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

P450 enzymes constitute a family of monooxygenase enzymes involved in the metabolism of a wide array of endogenous and xenobiotic compounds. Several P450 enzymes are classified by sequence similarities as members of the CYP1A and CYP2A subfamilies.
CYP51A1 (cytochrome P450, family 51, subfamily A, polypeptide 1), also known as LDM (lanosterol 14-alpha demethylase) or cytochrome P450-14DM, is a 503 amino acid protein localized to the endoplasmic reticulum membrane.
CYP51A1 is an important enzyme for zymosterol and steroid biosynthesis, catalyzing C14-demethylation of lanosterol to form 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
It is ubiquitously expressed, with highest levels found in liver, ovary, testis, lung, kidney, and prostate.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.