Thermo Fisher Scientific RFC1 Polyclonal Antibody
RFC1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 검증 완료. 고순도 항원 친화 크로마토그래피 정제 제품으로 DNA 복제 및 수리 연구에 적합. -20°C 보관, 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human RFC1 (46–64aa NSSRKEDDFKQKQPSKKKR) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide, 0.05 mg thimerosal |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2747038 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Replication factor C (RFC) is an essential DNA polymerase accessory protein required for DNA replication, repair, and telomere metabolism. RFC forms a heteropentameric complex that recognizes primer-template junctions and loads proliferating cell nuclear antigen (PCNA) onto DNA in an ATP-dependent manner. All five RFC subunits share related sequences (RFC boxes) including nucleotide-binding motifs. RFC1, RFC2, RFC3, and RFC4 contain consensus ATP-binding motifs. The smaller RFC proteins (RFC2–RFC5) interact with Rad24, whereas RFC1 does not. RFC2 exhibits ATP binding critical for DNA replication and checkpoint function.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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