Thermo Fisher Scientific Factor XIII B Recombinant Rabbit Monoclonal Antibody (105)

Applications

ELISA (ELISA)

• Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to the rabbit immune repertoire

This antibody specifically recognizes Human Coagulation Factor XIII B chain/F13B.

Target Information

The Factor XIII B subunit gene encodes a component of coagulation factor XIII, the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer of two A subunits (catalytic) and two B subunits (non-enzymatic, carrier role). Platelet factor XIII contains only A subunits.
Upon thrombin activation and in the presence of calcium ions, plasma factor XIII releases B subunits and forms the active enzyme factor XIIIa, a transglutaminase that crosslinks fibrin molecules to stabilize the clot.
Factor XIII deficiency is categorized as:

• Type I: lack of both A and B subunits
• Type II: lack of A subunit only

Deficiency can cause lifelong bleeding tendency, impaired wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.