Thermo Fisher Scientific BCL6 Monoclonal Antibody (BCL-UP), APC, eBioscience
BCL6 단클론 항체(BCL-UP)는 인간 B세포 및 림프종 연구용으로 적합한 APC 형광 표지 항체입니다. Flow Cytometry에 최적화되어 있으며, 5 µL/test로 사용됩니다. Bcl-6 단백질의 발현 분석 및 세포 내 염색에 활용됩니다.
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Thermo Fisher Scientific BCL6 Monoclonal Antibody (BCL-UP), APC, eBioscience™
Applications and Tested Dilution
- Application: Flow Cytometry (Intracellular staining)
- Tested Dilution: 5 µL (0.125 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BCL-UP |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11042117 |
Product Specific Information
Description:
Monoclonal antibody BCL-UP recognizes Bcl-6 (B-cell lymphoma 6), a POZ family transcriptional repressor. Bcl-6 is abundantly expressed in germinal center B cells and activated B cells. This 79 kDa protein is crucial for germinal center B cell proliferation and survival, and promotes pre-B cell survival during development. It is constitutively expressed in diffuse large B cell lymphomas (DLBCLs), Burkitt’s lymphoma, and non-Hodgkin’s lymphoma. Expression is also observed in CD4+ T follicular helper and memory T cells. Bcl-6 is antagonized by Blimp-1.
Applications Reported:
- Intracellular staining followed by flow cytometric analysis.
Applications Tested:
- Tested in human tonsil cells using Foxp3 Fixation/Permeabilization Buffers (Product # 00-5521-00).
- Refer to BestProtocols® for detailed staining procedures (Protocol B).
- Recommended usage: 5 µL (0.125 µg) per test (approx. 10⁵–10⁸ cells/test).
Excitation/Emission:
- Excitation: 633–647 nm
- Emission: 660 nm
- Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
Bcl-6 proto-oncogene product is a Kruppel-type zinc-finger protein expressed in normal germinal center B cells and related lymphomas. It is involved in chromosome rearrangements at 3q27 in non-Hodgkin’s lymphomas, detected in 33–45% of diffuse large B cell lymphomas. Bcl-6 expression is confirmed immunohistochemically in follicular lymphoma, diffuse large B cell lymphoma, Burkitt’s lymphoma, and nodular lymphocyte predominant Hodgkin’s disease.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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