Thermo Fisher Scientific Human CADPS2 Synthetic Peptide

Thermo Fisher Scientific Human CADPS2 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 19 amino acids near the center of human CAPS2.
PEP-0638 can be used as a blocking peptide with polyclonal antibody PA5-20518.

Target Information

CAPS2 and the related protein CAPS1 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca²⁺-regulated exocytosis of secretory vesicles. CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. Like CAPS1, numerous isoforms of CAPS2 are known to exist, showing distinct expression patterns in the brain. For example, CAPS2b exhibits high expression in the developing cerebellum. Furthermore, a version of CAPS2 mRNA lacking exon 3 is detected in some autistic patients, suggesting that differential expression of CAPS2 is involved in neuronal development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.