Thermo Fisher Scientific MSK1 Recombinant Superclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Pig, Rat, and Mouse.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies, and providing consistent performance across lots.

While functionally similar to polyclonal antibodies—recognizing multiple epitope sites and offering high detection sensitivity for low-abundance targets—Superclonal™ antibodies have a defined mixture of light and heavy chains, ensuring reproducibility and eliminating biological variability.

Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and performance remain unchanged.

Target Information

RPS6KA5 (MSK1) is a serine/threonine protein kinase essential for regulating various cellular processes. It mediates mitogen- or stress-induced phosphorylation of transcription factors such as CREB1 and ATF1, and regulates RELA, STAT3, and ETV1/ER81. MSK1 contributes to gene activation via histone phosphorylation and plays a role in inflammatory gene regulation.

It phosphorylates CREB1 and ATF1 in response to stimuli like UV-C irradiation, EGF, and anisomycin. MSK1 controls RELA transcriptional activity in response to TNF and glucocorticoids, associates with glucocorticoid receptor NR3C1, and represses inflammatory gene expression. In skeletal myoblasts, it phosphorylates RELA at Ser-276 during oxidative stress, and in erythropoietin-stimulated cells, it mediates Ser-727 phosphorylation of STAT3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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