Thermo Fisher Scientific DLL4 (delta-like 4) Monoclonal Antibody (HMD4-2), PE

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Additional Formats

• Unconjugated (MA5-28213)
• Request custom conjugation

Product Specific Information

• Reconstitute with 1.0 mL distilled water.
• Each vial contains sample for 100 tests per 1 mL.
• Hamster anti-Mouse Delta-Like Protein 4 antibody, clone HMD4-2, recognizes mouse DLL4 — one of the five major ligands of the Notch signaling pathway. This pathway is activated through binding of specific ligands to Notch receptors (Notch1–4).

Target Information

Delta-like ligand 4 (DLL4), also known as Delta-4, is a transmembrane ligand for the Notch1 receptor. It is expressed in the vasculature and plays a critical role in vascular development. DLL4 is induced by VEGF and acts as a negative feedback regulator of angiogenic sprouting, promoting formation of a differentiated vascular network.
DLL4 is strongly expressed in tumor vessels of clear-cell renal and bladder cancers. Inhibition of DLL4 increases vascular proliferation but impairs maturation, resulting in decreased tumor growth without apparent toxicity.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지