Thermo Fisher Scientific Placental Alkaline Phosphatase Polyclonal Antibody
사람 태반 유래 알칼라인 포스파타제(AP)를 인식하는 양 폴리클로날 항체. Western blot, ELISA, Immunomicroscopy에 사용 가능. 태반 및 골 AP 모두 반응. 5 mg/mL 농도의 액상형, 4°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
ELISA (ELISA)
- Tested Dilution: Assay-dependent
Immunomicroscopy (IM)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified alkaline phosphatase from human placenta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2289511 |
Product Specific Information
This antibody has been found to be reactive with both placental and bone alkaline phosphatase.
Sheep anti-human alkaline phosphatase antibody recognizes alkaline phosphatase and reacts with both placental and bone alkaline phosphatase.
Target Information
Placental Alkaline Phosphatase (PLAP) plays an important role in regulating specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney isoforms.
PLAP reacts with a membrane-bound isoenzyme (Regan and Nagao type) occurring in the placenta during the third trimester of gestation. It is useful in identifying testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA).
A proposed function of PLAP is matrix mineralization; however, mice lacking a functional form of this enzyme show normal skeletal development. PLAP has been linked to hypophosphatasia, a disorder characterized by hypercalcemia and skeletal defects. The severity of hypophosphatasia varies depending on the specific mutation involved.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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