Thermo Fisher Scientific Placental Alkaline Phosphatase Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

ELISA (ELISA)

• Tested Dilution: Assay-dependent

Immunomicroscopy (IM)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This antibody has been found to be reactive with both placental and bone alkaline phosphatase.
Sheep anti-human alkaline phosphatase antibody recognizes alkaline phosphatase and reacts with both placental and bone alkaline phosphatase.

Target Information

Placental Alkaline Phosphatase (PLAP) plays an important role in regulating specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney isoforms.
PLAP reacts with a membrane-bound isoenzyme (Regan and Nagao type) occurring in the placenta during the third trimester of gestation. It is useful in identifying testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA).

A proposed function of PLAP is matrix mineralization; however, mice lacking a functional form of this enzyme show normal skeletal development. PLAP has been linked to hypophosphatasia, a disorder characterized by hypercalcemia and skeletal defects. The severity of hypophosphatasia varies depending on the specific mutation involved.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.