Thermo Fisher Scientific CDC27 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CDC27 protein. Validated for Western blot and immunoprecipitation. Predicted cross-reactivity with mouse, rat, and bovine. Liquid form with 0.20 mg/mL concentration, stored at 4°C. For research use only.
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- A301183Ax (2개 옵션)
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 225 and 275 of human cell division cycle 27 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse, Rat, and Bovine
Target Information
The CDC27 protein shares strong similarity with Saccharomyces cerevisiae Cdc27 and Schizosaccharomyces pombe nuc2. It is a component of the anaphase-promoting complex (APC), composed of eight conserved subunits in eukaryotic cells. APC catalyzes the formation of cyclin B–ubiquitin conjugates, mediating proteolysis of B-type cyclins. CDC27 and three other APC members contain the TPR (tetratricopeptide repeat) domain, which facilitates protein-protein interactions. The protein interacts with mitotic checkpoint proteins such as Mad2, p55CDC, and BUBR1, potentially regulating mitosis timing. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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