Thermo Fisher Scientific PHC1 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PHC1 (AAH73964.1, 1 a.a. approximately 957 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PHC1,uniProtId:P78364-1,ncbiNodeId:9606,antigenRange:1-1004,antigenLength:1004,antigenImageFileName:H00001911-D01P_PHC1_P78364-1_Rabbit.svg,antigenImageFileNamePDP:H00001911-D01P_PHC1_P78364-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: METESEQNSN STNGSSSSGG SSRPQIAQMS LYERQAVQAT IAASRQASSP NTSTTQQQTT TTQASINLAT TSAAQLISRS QSVSSPSATT LTQSVLLGNT TSPPLNQSQA QMYLRVNRTL GRNVPLASQL ILMPNGAVAA VQQEVPSAQS PGVHADADQV QNLAVRNQQA SAQGPQMQGS TQKAIPPGAS PVSSLSQASS QALAVAQASS GATNQSLNLS QAGGGSGNSI PGSMGPGGGG QAHGGLGQLP SSGMGGGSCP RKGTGVVQPL PAAQTVTVSQ GSQTEAESAA AKKAEADGSG QQNVGMNLTR TATPAPSQTL ISSATYTQIQ PHSLIQQQQQ IHLQQKQVVI QQQIAIHHQQ QFQHRQSQLL HTATHLQLAQ QQQQQQQQQQ QQPQATTLTA PQPPQVPPTQ QVPPSQSQQQ AQTLVVQPML QSSPLSLPPD AAPKPPIPIQ SKPPVAPIKP PQLGAAKMSA AQQPPPHIPV QVVGTRQPGT AQAQALGLAQ LAAAVPTSRG MPGTVQSGQA HLASSPPSSQ APGALQECPP TLAPGMTLAP VQGTAHVVKG GATTSSPVVA QVPAAFYMQS VHLPGKPQTL AVKRKADSEE ERDDVSTLGS MLPAKASPVA ESPKVMDEKS SLGEKAESVA NVNANTPSSE LVALTPAPSV PPPTLAMVSR QMGDSKPPQA IVKPQILTHI IEGFVIQEGA EPFPVGCSQL LKESEKPLQT GLPTGLTENQ SGGSLGVDSP SAELDKKANL LKCEYCGKYA PAEQFRGSKR FCSMTCAKRY NVSCSHQFRL KRKKMKEFQE ANYARVRRRG PRRSSSDIAR AKIQGKCHRG QEDSSRGSDN SSYDEALSPT SPGPLSVRAG HGERDLGNPN TAPPTPELHG INPVFLSSNP SRWSVEEVYE FIASLQGCQE IAEEFRSQEI DGQALLLLKE EHLMSAMNIK LGPALKICAK INVLKET

Target Information

Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development. PHC1 (polyhomeotic homolog 1), also known as EDR1, HPH1 or RAE28, is a 1,004 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Existing as a homodimer, PHC1 contains one FCS-type zinc finger and a SAM (sterile alpha motif) domain. PHC1 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.